From Rome on the A1 super-highway, exiting at the Chiusi-ChianchianoTerme exit (n°29):
Follow the signs towards Chianciano-Montepulciano and, once at Montepulciano, the signs for Nottola. After three or four kilometres, you will find the signs which indicate how to arrive at Valdipiatta, a right turn off the Montepulciano-Nottola road.

From Florence on the A1 superhighway, exiting at the Valdichiana exit (n°28):
Follow the signs which indicate Montepulciano via Nottola and, once at the Nottola crossroads, continue for three or four kilometres towards Montepulciano. The sign indicating the turn-off for Tenuta Valdipiatta is on the left.